POLYMOSITIS—-1/3—DERMATOMYOSITIS(ASSOC. SKIN RASH)

CHRONIC IDIOPATHIC AUTOIMMUNE INFLAMMATORY MYOPATHY WITH PROXIMAL MUSCLE WEAKNESS, TIREDNESS, AND WASTING

OTHER INFLAMMATORY MYOPATHIES CAN BE INFECTIOUS(TRICHINOSIS)

“TIRED CLIMBING THE STAIRS”–MYOGENIC (STRIATED MUSCLE) USUALLY LEADS TO PROX LIMB WEAKNESS “ARMS TIRED DOING HAIR”–FIBRILLATION POTENTIALS ON EMG

BIMODAL (5-15) AND (40-60)

FEMALE 2:1

GOTTRON’S PAPULES

= PATHOGNEUMONIC ERYTHEMATOUS PLAQUES ON DORSAL KNUCKLES

VIOLACEOUS HELIOTROPE RASH

UNDER THE EYES

1/3 OF PTS HAVE UPPER ESOPHAGEAL AND PHARYNGEAL DYSMOTILITY–UPPER1/3 OF THE ESOPHAGUS(VS LOWER 2/3 IN SCLERODERMA)

DYSARTHRIA, DYSPHAGIA, NASAL REGURGE, ASPIRATION, HOARSENESS, SOB, TONGUE WEAKNESS

ANTI JO-1 Ag Ab (IgG)

HIGH CPK, LDH-5, AND ALDOLASE (MUSCLE ENZYMES)

FIBRILLATION POTENTIALS ON EMG

ASSOC WITH ANOTHER MALIGNANCY 9-14%—LUNG, PROSTATE, OVARY, UTERUS, BREAST

ASSOC WITH OTHER AUTOIMMUNE Dz–SLE, SCLERODERMA

Rx: SYMPTOMATIC, STEROIDS, MTX, CLOSE OBSERVATION