SAMPTER’S TRIAD—-ASA INDUCED ASTHMA

ASPIRIN/ASTHMA/SAMPTER’S/SAINT’S TRIAD
SYNDROME OF ASA INTOLERANCE, ASTHMA, AND NASAL POLYPOSIS
NOT ALLERGIC!  AN ANOMALY ISN ARACHIDONIC ACID METABOLISM
MALE = FEMALE

83% WILL HAVE ETOH SENSITIVITY, 75% NASAL CONGESTION AND 51% WHEEZING

LEUKOTRIENE INHIBITORS SEEM TO ALLOW ASA DESENSITIZATION IN A MUCH SAFER ENVIRONMENT

USUALLY EMBARK ON ASA DESENSITIZATION ABOUT 2 WEEKS POST SURGERY

ASA DESENSITIZATION SEEMS TO ALLOW ETOH CONSUMPTION

NEED TO KEEP THEM ON 650 BID FOR AWHILE TO GET THERE

CAN RE OPERATE ON PTS ON ASA WITHOUT MUCH MORE BLOOD LOSS

GET PT PREPARED TO DO BUDESONIDE IRRIGATIONS REGULARLY

BIOLOGICS SUCH AS XOLAIR OR MEPOLIZUBAB MAY WORK WONDERS—JURY STILL OUT