COGAN’S SYNDROME

“Non-Syphilitic Interstitial Keratitis”

A Systemic Vasculitis (Probably Autoimmune in Etiology)–HYDROPICSYMPTOMS WITH SPIRAL GANGLIONITIS

Primarily Affects Young Adults

FEMALE >MALE

1. Severe Episodic Vertigo/Nystagmus/ Ataxia/Unsteadiness

2. Progressive SNHL—MAY BE REVERSED WITH STEROIDS

3. Tinnitus

4. AURAL FULLNESS

Peripheral (Vs. central found in syphilis–USUALLY OLDER PTS) Fiery Episceritis “Corneitis/keratitis”

OTHER DIFF Dx = VOGT-KOYANIGI-HARADA SYNDROME (ALOPECIA AND EXUDATIVE UVEITIS) & SYPHILIS

1-2 WEEKS Malaise/Arthralgias

SKIN NODULES

Aortitis–AI

GI TRACT INVOLVEMENT

High ESR

Eosinophilia

Rx:

Ophthalmologic Consultation

Cyclophosphamide

Azathioprine

Prednisone

Steroid Eye Drops