ANTIBIOTICS
PCN
BACTERIOCIDAL
–5% RASH
1/10,000 ANAPHYLAXIS
PENETRATE THE CSF
NOT GOOD FOR H.INF
DICLOX—DOC FOR STAPH
AMINOPCN—AMOX & AMPICILLIN
NOT GOOD FOR S.a.
80% OF H. INF ARE SUSCEPTIBLE
NOT GOOD FOR M. CAT OR PSEUDOMONAS
STILL DOC FOR URTI
SBE = STREP VIRIDANS
2 G P.O. 1 HOUR OCOR IS NOW STANDARD SBE PROPHYLAXIS (JAMA-97)
AUGMENTIN AND UNASYN—-GOOD FOR G+ AND ANAEROBES
TICARCILLIN AND PIPERCILLIN—-GOOD FOR PSEUDOMONAS AND SYNERGISTIC WITH AMINOGLYCOSIDES
CEPHALOSPORINS—-COUSIN TO THE PENICILLINS—10-15% CROSS RXN IN ALLERGIC PTS
GOOD CSF PENETRATION
1ST GENERATION—-G+
3RD GENERATION—G-
KEFLEX
CEFUROXIME
POOR H. INF COVERAGE
POOR PSUEDOMONAS COVERAGE
POOR BACTEROIDES COVERAGE
BETA-LACTAMS
IMIPENUM
MACROLIDES
BACTERIOSTATIC
ALL USE THE P450 ENZYME SYSTEM (THEOPHYLLIN, COUMADIN, SELDANE, CIMETIDINE, DILANTIN,ANTI-FUNGALS, PHENOBARB—)
GOOD FOR MYCOPLASMA AND HEMOPHILIS
EYRYTHROMYCIN—-DOC FOR DIPTHERIA AND LEGIONELLA AND BORDATELLA PERTUSSIS
BIAXIN
AZITHROMYCIN—-THEORETICALLY TRANSPORTED ON THE WBC—IMPROVES EFFICACY
SULFA
HIGH INCIDENCE OF FIXED DRUG RXNS
VANCOMYCIN
OTOTOXIC
NEPHROTOXIC
“RED MAN SYNDROME”
AMINOGLYCOSIDES
OTO, NEPHRO, NMJ–TOXIC
FLAGYL
NITROFURANTOIN
——CAN ALL LEAD TO PERIPHERAL NEUROPATHIES
TETRACYCLINE
BINDS WITH CA++
MAY HELP WITH APTHOUS STOMATITIS
CHLORAMPHENICOL
1/24,000—-APLASTIC ANEMIA
GREY BABY SYNDROME
FLOROQUINOLONES
BACTERIOCIDAL
CIPRO, TROVAN, LEVAQUIN
DOC (ONLY ORAL AGENT) AGAINST PSEUDOMONAS—-EXCELLENT BONE ABSORBTION (8 X)
POOR ACTIVITY AGAINST ANAEROBES
INHIBITS BACTERIAL TOPOISOMERASE II
INTERFERES WITH CARTILAGE GROWTH
LINCOSAMIDES
CLEOCIN
BACTERIOSTATIC
NOTED S.A. IS PSEUDOMEMBRANOUS COLITIS (C. DIFF)
EXCELLENT BONE ABSORBTION
THEORETICALLY INHIBITS THE PRODUCTION OF TOXIN FROM VIRULENT STREP IN NECROTIZING FASCIITIS
INH
AMPHO B
AMPHOTERRIBLE
LONG TERM RENAL FAILURE
MEBENDAZOLE
INTESTINAL PARASITES