GRANULAR CELL TUMOR–GRANULAR CELL MYOBLASTOMA
NEURAL ORIGIN(+S-100, NEURON SPECIFIC ENOLASE, +PAS)
PROBABLY OF SCHWANN CELL ORIGIN
10% MULTICENTRIC, 5% RECURRENCE
PREPONDERANCE FOR H&N > 50%(PRIMARILY THE DORSAL TONGUE)
PRIMARILY PRESENT AS A PAINLESS MASS
MAY ALSO PRESENT ON THE POST TVC’S OR ARYTENOIDS
DESCRIBED BY ABRIKOSSOF IN 1926
FEMALE 2:1
BLACKS>WHITES
2% MALIGNANT
OVERLYING EPITHELIUM MAY SHOW PSEUDOEPITHELIOMATOUS HYPERPLASIA–APPEARS THAT EPITHELIUM MAY BE THE SOURCE BUT IT IS SECONDARILY AFFECTED—–CAN BE MISTAKEN FOR SCCA—SYPHILIS, BLASTO, TB, PACHYDERMA LARYNGIS, RT CHANGES, PAPILLARY KERATOSIS