Eosinophilic Esophagitis (EoE) Treatment Options

Until recently, esophageal eosinophilia was primarily attributed to acid reflux esophagitis. Allergic patients who developed swallowing problems and intestinal symptoms underwent endosocopy and white blood cells called eosinophils were found infiltrating the mucosa. Even though we associate eosinophils with allergy, we did not make that clinical connection until recently.

In the last five years, eosinophilic esophagitis—also known as allergic esophagitis, primary eosinophilic esophagitis, and idiopathic eosinophilic esophagitis—has emerged as an important independent allergic condition found to occur in children and in adults.

Comprehensive allergy testing and immunotherapy for inhalant allergies have proven effective. That is, aggressively treating inhalant allergies with immunotherapy (allergy shots or drops) helps in treating eosinophilic esophagitis. Immunotherapy for food allergies is still being studied.

Singulair, carafate, and chromolyn may be helpful. Xolair and IL-5 inhibitor are still experimental. Food allergy testing is always completed and elimination diets are considered. A trial of an elemental amino acid diet may be entertained, but is rarely practical.

Eosinophilic Esophagitis (EoE) Treatment Options:
1) Swallowed Fluticasone.  (Shake the inhaler for 15 seconds immediately before use.  Do not attach a spacer.  Breathe out through your mouth and then close your lips around the mouth piece.  Hold your breath, press down on the top of the metal canister and swallow.  Do not breath in until the medication is swallowed.  After swallowing, breathe normally.  Wait 15 seconds.  If your were instructed to take two puffs, repeat the above steps.  Replace the mouthpiece cap after each use.  Do not rinse your mouth, eat or drink for 30 minutes following each use.  Each inhaler contains about 120 puffs and will last 30 days taking two puffs twice daily.

You can also use Budesonide mixed with Splenda instead of Fluticasone if you like.
 (Open the Budesonide container and transre teh liquid into a cup.  Add three to 10 packets of Splenda artificial sweetner and mix with a spoon.  Swallow.  Do night rinse your mouth, eat of drink for 30 minutes after taking it.)   The sucralose contained in Slenda forms a thick solution that will coat the esophagus.  Other artificial sweeteners do not do this.

2) Targeted dietary avoidance based on results of skin prick and patch testing to foods. If not successful, I then try empiric elimination diet. Rarely have I needed to resort to elemental diet (in a case of a child with severe oral aversion).
3) Aggressive management of aeroallergen hypersensitivity (can also trigger GI eosinophilia), that is Avoidance, Medications, and Allergy Shots. Singulair is helpful in about one half of the patients.
4) Proton Pump inhibitor (often 2 times per day) These patients generally get scoped quite frequently to monitor their progress. Dysphagia must sometimes be treated by esophageal dilatation.