Bacterial Antigens for Immunotherapy

bacterial_vaccineIn 1979 the Federal Register of the FDA issued a final rule classifying a group of Bacterial Vaccines and Bacterial Antigens with “no U.S. Standard of potency” based on the review of a Panel Recommendations. Because they had insufficient data to support their safety and efficacy. The products never did studies as the manufacturers were not interested in the cost and they were withdrawn. Despite no documented scientific evidence supporting efficacy allergist had given these tablets for over 1/2 century without any adverse effects and many attested to there effectiveness at stopping recurrent upper respiratory infections. We knew most were viral but these bacterial antigens seemed to work.

In 2009 Dr. Bellanti produced a supplement to the Allergy Proceedings on new vaccine of ribosomal nature associated with glycoprotein cell walls from Klebsiella pneumoniae which served as an immunoadjuvant. From the articles it seems the ribosomes stimulate TLR2 and work on the innate immune system and boost the adaptive system.

If you live long enough you see a lot of old ideas recycled. I have some old vaccines from the 50’s and thought the younger allergist would get a kick out of seeing this stuff and a heads up to all of us to watch for a immunomodulator that may be coming soon.