RHEUMATOID ARTHRITIS (RA)

SYSTEMIC (SYMMETRIC) PERIPHERAL AUTOIMMUNE SYNOVITIS

FEMALE 3:1

H&N MANIFESTATIONS: TMJ, C-SPINE, CRICO-ARYTENOID JOINT INVOLVEMENT, POSSIBLE ISCHEMIC RLN PARESEIS-HOARSENESS AND ARYTENOID ERYTHEMA, ABNL GLOTTIC POSITION, FLACCIDITY OF THE TYPMPANIC MEMBRNES

POSITIVE RHEUMATIOD FACTOR(IgG)TITERS–BINDS COMPLEMENT–DECREASED COMPLEMENT IN SYNOVIAL FLUIDS

25% SUB Q RHEUMATOID NODULES. ULNAR DEVIATION

PRIMARILY AFFECTS THE PROXIMAL JOINTS OF THE HANDS AND FEET

LEADS TO ANKYLOSIS(FUSION) AND INSTABILITY(SUBLUXATION)

VARIANTS

STILL’S Dz

= JUVENILLE RA (1-3 YEARS OLD, FEMALE PREPONDERANCE)

ACUTE FEBRILE ONSET, IRIDOCYCLITIS, RASH, ANEMIA, LAD, PERICARDITIS, RASH, H-S MEGALY

FELTY’S SYNDROME

H-S MEGALY, LEUKOPENIA, ANT LOWER LEG ULCERS, SICCA COMPLEX

ANKYLOSING SPONDYLITIS

HLA-B27, YOUNG MEN

IDIOPATHIC, POKER (BAMBOO) SPINE, KYPHOSIS, S-I JOINTS, UVEITIS, PULM FIBROSIS

Rx: ANTIINFLAMMATORIES, ANTIMETABOLITES