EXTRAMEDULLARY PLASMACYTOMA
RISK FACTORS : AGE, RACE, RADIATION—-NOT SMOKING OR ETOH
PLASMACYTOAM—THREE VARIANTS: MULTIPLE MYELOMA, SOLITARY PLASMOCYTOMA OF BONE, EXTRAMEDULLARY(OUT OF THE BONE MARROW)
ANY OF THESE CAN PROGRESS TO MM(30-70%)
CLOCK-FACE PLASMA CELL ON H & E
MM SURVIVAL MEAN 2-3 YEARS—-USUALLY RENAL FAILURE OR INFXN
CAN BE PART OF MULTIPLE MYELOMA—ALWAYS WORK THIS UP—SERUM AND URINE ELECTOPHORESIS (BENCE JONES PROTIENS) IMMUNOPEROXIDASE STAINING FOR IGA AND IGG LIGHT CHAINS, LABS, BM Bx, IMAGING—–Rx = CHEMO
RARE, 85% IN THE H&N
PINK/RED–POLYPOID OR SESSILE
USUALLY IN THE NC,SINUSES OR NP
IF ISOLATED–Rx = RT!—-CAN DO SURGICAL RESECTION—–CHEMO WITH BM TRANSPLANT IS A LAST OPTION