PLUMMER-VINSON SYNDROME (PVS)—PATTERSON-KELLY-BROWN SYNDROME—SIDEROBLASTIC DYSPHAGIA—SIDEROPENIC DYSPHAGIA

HIGH INCIDENCE WITH SCANDINAVIAN DESCENT

PRIMARILY NORTHERN HEMISPHERE

FEMALE 9:1

COMMONLY ASSOC. WITH HYPOTHYROIDISM

USUALLY AGE 20-50

90% OF PTS EDENTULOUS

50% INCIDENCE OF MULT CIRCULATING ANTIBODIES

HIGH INCIDENCE (UP TO 50%) OF POST CRICOID (PARTY WALL) AND CERVICAL ESOPHAGEAL CARCINOMAS (ALSO OP/OC)

DYSPHAGIA (86% UPPER ESOPHAGEAL/PHARYNGEAL WEBS)—ATROPHIC DEGENERATION OF PHARYNGEAL AND ESOPHAGEAL MUSCULATURE

BLUE SCLERA

ACHLORHYDRIA (35%)

ATROPHIC GASTRITIS (40%)

PERLECHE = ANGULAR CHELITIS/CHEILOSIS = FISSURES AT THE CORNERS OF THE MOUTH

ATROPHIC GLOSSITIS–ASH GRAY ORAL MUCOSA

SPLENOMEGALLY

(IDA) IRON DEFICEINCY ANEMIA

MICROCYTIC, HYPOCHROMIC, ANISOCYTOSIS (RDW>14)

PICA (COMPULSIVE CONSUMPTION OF NON-NUTRITIVE SUBSTANCES)—PAGOPHAGIA (ICE)

KIOLONYCHIA (SPOON NAILS)–FURROWED FINGER AND TOE NAILS

PALLOR, TACHY

Dx = MODIFIED BARIUM SWALLOW, CBC WITH PBS