Tumor Classification

TUMOR CLASSIFICATION
THYROID TUMORS ARE ALL ENDODERMAL (POUCH) DERIVATIVES EXCEPT MEDULLARY (NEURAL CREST DERIVATIVES/ECTODERMAL) PARAFOLLICULAR C-CELLS FROM THE ULTIMOBRANCHIAL BODY
MESENCHYMAL—MESODERM
LYMPHOMAS—MESENCYMALLY DERIVED LYMPHORETICULAR MALIGNANCIES
HODGKINS DISEASE
NHL
BURKITTS
EXTRANODAL ANGIOCENTRIC PERIPHERAL T-CELL LYMPHOMAS—ALL BETTER DEFINED SINCE THE ADVENT OF IMMUNOHISTOCHEMICAL STAINING
HISTIOCYTOSIS X = RETICULOENDOTHELIOSIS = (LCH) LANGERHANS CELL HISTIOCYTOSIS
LETTERER-SIWE (“BETTER SEND A LETTER”)–ERICH LETTERER 1924
HAND-SCHULLER-CHRISTIAN Dz–ALFRED HAND–PEDIATRICIAN 1893
EOSINOPHILIC GRANULOMA (EG) OF BONE
POLYMORPHIC RETICULOSIS —-SINONASAL LYMPHOMA
SYNONOMOUS WITH MIDLINE GRANULOMATOUS OR DESTRUCTIVE DISEASES—LEATHAL MIDLINE GRANULOMA
REALLY AND EXTRANODAL PERIPHERAL ANGIOCENTRIC T-CELL LYMPHOMA
ORBITAL PSEUDOTUMOR—-INFLAMMATORY PSEUDOTUMOR—-PSEUDOLYMPHOMA
OFTEN PRESENT AS AN ORBITAL MASS—PERIVASCULAR CUFFING
SALIVARY GLAND TUMORS ARE ALL ECTODERMAL
ADNEXAL TUMORS
SEBACEOUS GLAND=MOST COMMON
—-OF THE MEIBOMIAN GLAND—USUALLY PRESENT AS ULCERATED NODULAR LESOIN OF THE PALPEBRAE
SWEAT GLAND
APOCRINE OR ECCRINE GLAND CA—PROPENSITY FOR UPPER FACE—PROPENSITY FOR PERINEURAL INVOLVEMENT—CAN BE MISREAD AS BCCA—MOHS IS BEST—CONSIDER POST OP RT
HAIR FOLLICLES
TRICHOLEMMAL CA OR MALIGNANT TRICHOLFOLLICULOMA
PILOMATRIXOMA—”OF MALHERBE”
MESENCHYMAL TUMORS(VIMENTIN +)
ATYPICAL FIBROXANTHOMA
MFH(MALIGNANT FIBROUS HISTIOCYTOMA)
DFSP (DERMATO FIBRO SARCOMA PROTUBERANS) (DARIER AND FERRAND–1924)
A DERMAL LAYER NODULAR SARCOMA WITH A HIGH PROPENSITY FOR LOCAL RECURRENCE AFTER SIMPLE EXCISION
A MALIGNANT MESENCHYMAL SPINDLE CELL NEOPLASM
15% OCCUR IN THE H&N
RARE-SARCOMAS ACCOUNT FOR LESS THAN 1 % OF HEAD AND NECK MALIGNANCIES
MEN > WOMEN
SMALL, UNIFORM, FIBROCYSTIC CELLS IN “CARTWHEEL” PATTERNS
NEED > 2 CM MARGIN AS THEY USUALLY EXTEND A LONG WAY–OPTIMALLY– 3 CM OF NL TISSUE SHOULD BE TAKEN–<10% RECURRENCE!
RARELY METASTASIZE
MOH’S IS A  GOOD OPTION–POSSIBLY—<3% RECURRENCE—MAX TISSUE CONSERVATION
RT IS PROBABLY BETTER THAN PREVIOUSLY THOUGHT (50% CURE) -8% RECURRENCE WITH QUESTIONABLE MARGINS
NEUROECTODERMAL—NEURAL CREST CELL TUMORS
NOTOCHORD= STRUCTURAL VESTIGE FORMED FROM MESODERM
EVENTUALLY BECOMES THE NUCLEUS PALPOSUS—VERTEBLRAL COLUM FORMS AROUND IT
STIMULATES NEURULATION PROCESS IN THE OVERLYING NEUROECTODERM
NEURULATION—-SOME OF THE NEUROECTODERM SEPERATES AN MIGRATES OUT TO FORM PERIPHERAL NEURAL STRUCTURES:
AFFERENT–DORSAL ROOT GANGLION
AUTONOMIC GANGLION—-SYMPATHETIC TRUNK, CN 3, 7, 9, AND 10 (GLOMUS CELL TUMORS—PARAGANGLIOMAS)
ADRENAL MEDULLA (CHROMAFFIN CELLS)—PHEOCHROMOCYTOMA
CELIAC,RENAL, INTESTINAL PLEXUS
SCHWANN CELLS—-SCHWANNOMA
MENINGES—PIA AND ARACHNOID (MENINGIOMA)
PIGMENT CELLS—-MELANOMA
IRIS CHROMATOPHORES
ULTIMOBRANCHIAL BODY—-PARAFOLLICULAR C-CELLS OF THE THYROID—-MEDULLARY CA OF THE THYROID
GRANULAR CELL TUMOR (DORSAL TONGUE)
NEUROBLASTOMA
ESTHESIONEUROBLASTOMA (OLFACTORY NEUROBLASTOMA)
NEUROECTODERMAL TUMOR OF INFANCY
CUTANEOUS TUMORS OF NERVES AND NEUROENDOCRINE CELLS
NEUROFIBROSARCOMA
MERKEL CELL CARCINOMA (TOKER 1972-ENDOCRINE CA OF THE SKIN)
GLOMUS CELL TUMOR—SYMPATHETIC INNERVATION—–REGULATES THE SUEQUET HOYER CANAL
CUTANEOUS TUMORS OF VESSELS
MALIGNANT ANGIOENDOTHELIOMA
KAPOSIS SARCOMA(SHOULD BE CALLED KAPOSIS ANGIOSARCOMA)
HEMANGIOPERICYTOMA —FROM THE CAPILLARY PERICYTE(EPITHELIAL ORIGIN) OF ZIMMERMAN

Posted by: on